Clinic-In-A-Box done for you with protocols, staff & patient education, waivers and how to market. The complete clinical foundation course in ozonated glycerin (OG) for licensed medical practitioners with prescribing and injection authority. Self-paced. Evidence-based. Built so the clinician who finishes can treat their first OG patient the week they finish the course.
By the end of this course you will be fully equipped to implement OG into your medical practice across every clinical route currently in use — oral, topical, mucosal, nebulizing, subcutaneous and intralesional injectables, intra-articular (PROG), intraperitoneal, and intravenous — with the protocols, handouts, patient consent waivers, fee schedule, phone scripts, and practice-launch playbook to run an OG service line on Monday morning.
A self-paced, on-demand course for licensed medical practitioners with prescribing and injection authority. It provides the foundational ozone knowledge required to practice ozonated glycerin (OG) safely, then teaches every OG application currently in clinical human-medicine use.
OG is a stable, slow-release form of ozone — pharmaceutical-grade glycerin infused with ozone gas, with a 90-day room-temperature half-life. Its 140-year clinical lineage — Charles Marchand’s nineteen books in the 1890s, Shiota’s rediscovery in Japan in 2001, Okamoto’s Japanese research program through 2018, and Dr. Frank Shallenberger’s North American clinical work alongside the OGPro Advisors — is what this course is designed to put into your hands.
"What you are about to learn is not miracle medicine. It is a useful, safe, adaptable therapy that belongs in the toolbox of any clinician who takes integrative medicine seriously."
Dr. Jim Bridge, DVM, CVA, FAAO · Module 1, Lesson 1.1
Licensed medical practitioners with prescribing and injection authority (MDs, DOs, NPs, PAs, and equivalents) in any specialty — primary care, integrative medicine, pain management, oncology support, regenerative medicine, urgent care, hospital practice — who want a clinically rigorous regenerative-medicine modality they can actually run on Monday.
Dentists who seek to understand the foundation of how to utilize ozonated glycerin to include the mucosal and oral applications. This is the foundational course and does not teach dental-specific procedures that are specific to the dental domain. The dental specific course will be given as an add-on for Dentists once developed.
Integrative and functional-medicine practitioners who already use modalities like prolotherapy, PRP, peptides, IV therapy, or neural therapy, and want to add a stable, safe, evidence-supported ozone delivery system to the toolkit.
Conventionally-trained licensed practitioners who keep running into chronic and refractory cases — non-healing wounds, treatment-resistant infections, refractory osteoarthritis, post-surgical complications, autoimmune-related inflammation — where conventional pharmacy has run out of options and the patient is asking what else is possible.
Practice owners building a regenerative or integrative service line and wanting a complete clinical-plus-business curriculum, not just a clinical CME.
Practitioners who already do ozone gas therapy and want to add OG — different formulation, different handling discipline, different indications — to expand the modalities they offer.
We are deliberate about scope. This course is not designed for, and does not authorize, use by:
Patients, family caregivers, or home users. The protocols, dose ranges, and consent frameworks in this course are clinician-specific and assume the prescribing authority and clinical judgment of a licensed medical practitioner.
Veterinarians. The OGPro Veterinary Foundation Course teaches OG for animal patients with species-specific protocols, livestock applications, and equine-specific routes that this course does not cover.
Practitioners without prescribing or injection authority. This course teaches injectable routes (SQ, intralesional, intra-articular, IP, IV) and assumes the legal and clinical authority to perform them. If your scope of practice does not include prescribing and injection, the OG content in this course exceeds your authority.
Anyone looking for an ozone-gas course. Insufflation (rectal, vaginal, aural), minor and major autohemotherapy, ozone bagging, and ozone saunas are not taught here — those are a different modality with their own equipment, safety profile, and evidence base.
Anyone looking for an ozonated-oils course. Ozonated olive, jojoba, and other carrier-oil formulations are a different chemistry with a different stability profile and different indications.
Practitioners hoping to make OG in-clinic. Producing injectable-grade OG requires concentration testing, contamination control, and stability verification outside this course’s scope. We assume you’ll source OG commercially. Module 7 covers sourcing, peroxide testing, the no-metal rule, and clinic storage in depth.
Thirteen modules across three sequential arcs. Each module unlocks when the prior one is complete; lessons unlock sequentially within a module; the end-of-module knowledge check must be passed at 70% or higher to advance.
Establishes what OG is and why it works.
Module 1 — Welcome, Scope, Practice Database, OGPro Learning Objectives, three-gate certification pathway, legal framework with practitioner-responsibility acknowledgment.
Module 2 — What OG Is: molecular structure, the time-release carrier mechanism, the 90-day half-life, stability profile, the no-metal rule (iron, silver, platinum).
Module 3 — Mechanism of Action: hormetic oxidative stress, Nrf2 pathway activation, cytokine modulation, antimicrobial spectrum, the Warburg effect and tumor-cell susceptibility.
Module 4 — The Glycocalyx, Endothelial Function and OG: the upstream lesion behind chronic inflammatory disease and OG’s biological rationale.
Module 5 — The 140-year clinical lineage: Marchand’s nineteen books (1890s) → Shiota 2001 → Okamoto 2018 → contemporary North American practice with Shallenberger and the OGPro Advisors.
Module 6 — The Japanese Research Evidence Base: Mediplus Pharma, Showa University, and Tottori University — twenty-five years of primary-source skin, hard-tissue, hemostatic, and antimicrobial studies in human medicine.
Every clinical route currently in human-medicine OG practice, taught against a single reusable 11-point clinical-protocol framework.
Module 7 — Sourcing, Testing & Storage. How to source quality OG, the peroxide test-strip protocol, batch logging, the no-metal discipline, the three-zone clinic storage protocol.
Module 8 — OG by Route I: Topical (10–100% with optional DMSO adjunct), Oral, Nebulizer and Nasal Spray, and Mucosal applications within the medical scope of practice.
Module 9 — OG by Route II (first injectable module): Subcutaneous Circle the Dragon for peritumoral application, intralesional infiltration, and the 3:3:3:1 Prolozone-with-OG (PROG) joint injection protocol for intra-articular use.
Module 10 — OG by Route III, Hospital-Based: Intraperitoneal OG (5% in warm saline), Intravenous OG (2.5% buffered), and Local Infusions (bladder Foley and other anatomically-targeted routes). Includes warming, sedation, monitoring, and emergency-response discipline.
Module 11 — OG & DMSO. When and how to add DMSO to topical and injectable OG protocols, with full safety and ratio reference cards.
Prepares you to actually run OG in your clinic and earn the credential.
Module 12 — Building a Successful OG Practice. Pricing philosophy, fee-schedule template, team operations, weekly case rounds, the 30-second elevator pitch, the five most common patient objections with scripted responses, the 6-step Marketing & Education Flywheel, the no-claims discipline, the 60-minute community seminar framework, and the colleague-referral playbook.
Module 13 — Capstone & Certification Cases. Submission of five case studies from your own practice across at least three indications, reviewed by an OGPro Advisor reviewer.
OG practice is a documentation discipline as much as a clinical one. The course ships with the operational paperwork already drafted, formatted, and ready to brand:
Patient consent and waiver forms — separate sheets for non-injectable, injectable (Module 9), and hospital-based IP/IV/local-infusion (Module 10) procedures
Patient-facing handouts for every route — written to go home in the discharge folder
Quick-reference dosing cards and dilution calculators (oral, topical, nebulizer, mucosal, SQ, intralesional, PROG, IP, IV, local infusion, DMSO ratios)
Procedure protocols printable for the clinic OG binder
Clinic storage protocol and peroxide testing log
Case study submission templates and the rubric they’re scored against
Fee-schedule template with regional adjustment ranges
Phone-script template, elevator-pitch card, and the 60-minute community seminar framework
Staff role cards for the OG-running clinic team
The Story
In 2018, Dr. Jim Bridge attended the American Academy of Ozone Therapy conference in Las Vegas. Dr. Toshikazu Okamoto of Tottori University, Japan, was presenting on ozonated water and cancer. The room was expecting more of the same — and it was the same — until the last two slides.
Those last two slides showed an ozone gel with a 90-day half-life at room temperature. A stable, deliverable, slow-release form of ozone — something the clinical ozone field had been looking for for over a hundred years.
Bridge cornered Dr. Okamoto after the talk to learn that Dr. Okamato was bubbling ozone through pharmaceutical-grade glycerin. Bridge went home and figured out how to make it.
Bridge went home and figured out how to make it.
What followed was a parallel discovery on two fronts. Bridge ran the veterinary case base — over 400 documented cases across seven years of small animal, equine, and large animal practice. Dr. Frank Shallenberger, Dr. Nola MacDonald DO, Jennifer Bull NP, and the other OGPro Advisors picked up the human-medicine case base, building on the same Marchand–Shiota–Okamoto lineage that had been published in Japanese medical journals for two and a half decades.
In 2025, Pam Holloway, RN, MS, founded the OGPro Collaborative as the certification body that would unite both case bases — animal and human — into a single rigorous training pathway. The Veterinary Foundation Course launched first. This is the parallel medical-practitioner course: every protocol drawn from the actual chart of an actual practice, every consent form drafted by clinicians who have used it on a Monday morning, every dose tested before it appears in a lesson.
To establish OG as a trusted, evidence-based tool — uniting physicians, dentists, veterinarians, and health innovators to pioneer oxygen-based healing worldwide. This Medical Practitioner Foundation Course is the second course of three.
These are the documented sources the course is taught from. They are not promises about your patients; they are the evidence base your patients’ protocols are built on.
Charles Marchand’s nineteen books (1890s, New York) — the founding clinical ozone literature that established ozone’s role in medicine more than a century before “regenerative medicine” had a name. Module 5 walks through what survived translation and what got lost.
from Mediplus Pharma, Showa University, and Tottori University — the dermatologic, mechanistic, hemostatic, hard-tissue, and stability evidence in human models that Module 6 walks you through paper by paper.
in seven years of veterinary practice — the largest systematic clinical OG case base in North America and the cross-species translational evidence that informs the Module 8–10 protocols.
— Dr. Nola MacDonald, DO; Jennifer Bull, NP; and colleagues — applying OG in human practice across the routes taught in Modules 8 through 10.
Self-paced. The reading content across 13 modules is roughly 18–22 hours total; most practitioners work through it across 6 to 12 weeks alongside clinical practice. The five-case certification submissions take longer because they require running real cases in your practice.
Course Complete means you finished all 13 modules and passed all 13 knowledge checks. A Certificate of Completion is available on request. It’s a completion marker, not a credential.
OGPro Certified Medical Practitioner is the credential. It requires Course Complete plus a 50-question cumulative Final Exam (≥70%, three attempts) plus five case studies submitted from your own practice across at least three indications, reviewed by an OGPro Advisor reviewer.
No. The course is designed to take a practitioner with zero prior ozone experience to first-OG-patient confidence. If you do have prior ozone-gas training, the Module 2 chemistry and Module 7 sourcing/handling content will still be new — OG has handling discipline that ozone gas does not.
OG is administered by the prescribing practitioner under your existing licensure. The course teaches what the OGPro Advisors do, what the published literature supports, and what common practice looks like; it does not substitute for your regulatory, clinical, or ethical obligations under your state medical, nursing, or PA practice act, applicable federal frameworks, or your professional standards. Module 1 walks through the legal framework and the practitioner-responsibility acknowledgment in detail.
OG is a glycerin-based formulation administered under the prescribing practitioner’s authority and the applicable off-label / non-approved-use framework. It is not an FDA-approved pharmaceutical product. The course teaches you to source from a manufacturer (PurO3 is the OGPro recommendation, with full affiliate disclosure in Module 7) on a cGMP-by-2027 roadmap with end-to-end chain of custody.
Not from this course. Producing injectable-grade OG requires concentration testing, contamination control, and stability verification that sit outside the course’s scope. We teach you to source it correctly, test it on receipt, store it discipline-fully, and use it precisely. Module 7 is dedicated to that whole chain.
Different modality, different course. Ozone gas therapy has its own equipment, safety profile, technique library, and evidence base. This course is OG only. We are deliberate about scope so the teaching and safety discipline both stay sharp.
Different formulation, different course. Ozonated olive, jojoba, and other carrier oils have different stability profiles and different indications. This course covers ozonated glycerin only.
A dedicated Dental OG course is in development. This medical-practitioner course teaches mucosal and oral applications within the medical scope of practice, but does not teach the dental-specific procedures (extraction-socket infusion, periodontal application, sinus flush) that belong to the dentist’s domain. We will announce the Dental course when it is ready.
14-day refund window from purchase date, before Module 2 unlock.
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No. Certified practitioners join the OGPro Practice Database — a de-identified case-pattern review, an ongoing community channel, and a colleague-referral network. The collaborative bargain is simple: submit your cases (the ones that worked, the ones that didn’t, the ones that surprised you), and OGPro feeds the aggregate findings back to the community as the curriculum evolves.
The course was built so the practitioner who finishes it can treat their first OG patient the week they finish. That is the bar. If that is the bar you want to meet, this is the course built for it.